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PLASWIRES 

"Engineering Multicellular Biocircuits: Programming Cell-Cell Communication Using PLASmids as WIRES" 

A Synthetic Biology FP7 European research project
PLASWIRES' main goal: To show how to program a parallel distributed living computer using conjugative plasmids as wires between cellular processors.
Rocío Lopez-Igual, Joaquín Bernal-Bayard, Alfonso Rodríguez-Patón, Jean-Marc Ghigo and Didier Mazel,  Engineered toxin-intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations, Nature Biotechnology, April 2019.   
https://doi.org/10.1038/s41587-019-0105-3 
https://www.nature.com/articles/s41587-019-0105-3 



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An animated gif describing our programmable antibiotic published in Nature Biotechnology: 
Picture





PLASWIRES Project ID card

  • Funded under: 7th FWP (Seventh Framework Programme)
  • Area: FET Proactive: Evolving Living Technologies (EVLIT) (ICT-2013.9.6)
  • Project reference: 612146
  • Total cost: 2.62 million euro
  • EU contribution: 2.01 million euro
  • Execution: From 2013-10-01 to 2016-09-30
  • Duration: 36 months
Participants

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Alfonso Rodríguez-Patón (Coordinator)
Universidad Politécnica de Madrid (Spain)
arpaton@fi.upm.es
arpaton@gmail.com
www.lia.upm.es
@LIA_UPM
Other partners:
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Fernando de la Cruz
Universidad de Cantabria (Spain)
fernando.cruz@unican.es 
http://grupos.unican.es/intergenomica/
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Jim Haseloff
University of Cambridge (UK) 
jh295@cam.ac.uk
http://www.haseloff-lab.org/
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Didier Mazel
Institut Pasteur (France) 
mazel@pasteur.fr
http://openwetware.org/wiki/Mazel

Description of PLASWIRES included in UPM Journal, n.28, June 2014 (in Spanish).
English version (in pdf):  Report on PLASWIRES and LIA research group